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Staphylococcus aureus capsular material promotes osteoclast formation.

Abstract:

Osteomyelitis, which is most frequently due to infection by Staphylococcus aureus, commonly causes bone destruction. S. aureus is known to secrete a number of surface-associated proteins that are potent stimulators of bone resorption. The precise cellular and humoral mechanisms that mediate this stimulatory effect are uncertain. In this study, we have determined whether osteoclast formation and resorption is directly promoted by surface-associated proteins. Surface-associated material (SAM) o...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Simpson, H More by this author
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Journal:
Injury
Volume:
37 Suppl 2
Issue:
2 SUPPL.
Pages:
S41-S48
Publication date:
2006-05-05
DOI:
EISSN:
1879-0267
ISSN:
0020-1383
URN:
uuid:94a88b87-8f58-4ccc-b7eb-9f30697d7914
Source identifiers:
103868
Local pid:
pubs:103868

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