Staphylococcus aureus capsular material promotes osteoclast formation.

Journal article

Osteomyelitis, which is most frequently due to infection by Staphylococcus aureus, commonly causes bone destruction. S. aureus is known to secrete a number of surface-associated proteins that are potent stimulators of bone resorption. The precise cellular and humoral mechanisms that mediate this stimulatory effect are uncertain. In this study, we have determined whether osteoclast formation and resorption is directly promoted by surface-associated proteins. Surface-associated material (SAM) o...

Expand abstract

Authors: Lau, Y; Wang, W; Sabokbar, A; Simpson, H; Nair, S

• Publication status: Published
• Journal: Injury
• Volume: 37 Suppl 2
• Issue: 2 SUPPL.
• Pages: S41-S48
• Publication date: 2006-05-01
• DOI: 10.1016/j.injury.2006.04.008
• EISSN: 1879-0267
• ISSN: 0020-1383
• Language: English
• Keywords: Osteoclasts; Humans; Bone Resorption; Tumor Necrosis Factor-alpha; Membrane Proteins; Macrophage Colony-Stimulating Factor; Lymphotoxin-alpha; Mice; Animals; RANK Ligand; Staphylococcus aureus; Interleukin-8