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High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders.

Abstract:

We previously discovered that mutations of the human FOXP2 gene cause a monogenic communication disorder, primarily characterized by difficulties in learning to make coordinated sequences of articulatory gestures that underlie speech. Affected people have deficits in expressive and receptive linguistic processing and display structural and/or functional abnormalities in cortical and subcortical brain regions. FOXP2 provides a unique window into neural processes involved in speech and language...

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Publication status:
Published

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Publisher copy:
10.1086/522238

Authors


Vernes, SC More by this author
Spiteri, E More by this author
Groszer, M More by this author
Taylor, JM More by this author
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Journal:
American journal of human genetics
Volume:
81
Issue:
6
Pages:
1232-1250
Publication date:
2007-12-05
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
URN:
uuid:94a4bb47-d7ad-4dfb-9212-c62aa8ccf259
Source identifiers:
34042
Local pid:
pubs:34042

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