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Journal article

Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses.

Abstract:

The inherited metabolic disorders of glycosphingolipid (GSL) metabolism are a relatively rare group of diseases that have diverse and often neurodegenerative phenotypes. Typically, a deficiency in catabolic enzyme activity leads to lysosomal storage of GSL substrates and in many diseases, several other glycoconjugates. A novel generic approach to treating these diseases has been termed substrate reduction therapy (SRT), and the discovery and development of N-alkylated imino sugars as effectiv...

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Publication status:
Published

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Publisher copy:
10.1093/glycob/cwi076

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
Glycobiology
Volume:
15
Issue:
10
Pages:
43R-52R
Publication date:
2005-10-05
DOI:
EISSN:
1460-2423
ISSN:
0959-6658
URN:
uuid:949cda2e-1477-4382-994f-bd190f4a6e5f
Source identifiers:
101024
Local pid:
pubs:101024

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