Journal article
Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses.
- Abstract:
-
The inherited metabolic disorders of glycosphingolipid (GSL) metabolism are a relatively rare group of diseases that have diverse and often neurodegenerative phenotypes. Typically, a deficiency in catabolic enzyme activity leads to lysosomal storage of GSL substrates and in many diseases, several other glycoconjugates. A novel generic approach to treating these diseases has been termed substrate reduction therapy (SRT), and the discovery and development of N-alkylated imino sugars as effectiv...
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- Publication status:
- Published
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- Publisher copy:
- 10.1093/glycob/cwi076
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Authors
Bibliographic Details
- Journal:
- Glycobiology
- Volume:
- 15
- Issue:
- 10
- Pages:
- 43R-52R
- Publication date:
- 2005-10-01
- DOI:
- EISSN:
-
1460-2423
- ISSN:
-
0959-6658
- Source identifiers:
-
101024
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:101024
- UUID:
-
uuid:949cda2e-1477-4382-994f-bd190f4a6e5f
- Local pid:
- pubs:101024
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2005
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