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Practical and analytical considerations when performing interim analyses in diagnostic test accuracy studies

Abstract:

Interim analysis is a common methodology in randomised clinical trials but has received less attention in studies of diagnostic test accuracy. In such studies, early termination for futility may be beneficial if early evidence indicates that a diagnostic test is unlikely to achieve a clinically useful level of diagnostic performance, as measured by the sensitivity and specificity. In this paper, we describe relevant practical and analytical considerations when planning and performing interim ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s41512-024-00174-4

Authors


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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0001-7205-2051
More by this author
Institution:
University of Oxford
Role:
Author
Publisher:
BioMed Central
Journal:
Diagnostic and Prognostic Research More from this journal
Volume:
8
Issue:
1
Article number:
12
Publication date:
2024-08-20
Acceptance date:
2024-06-24
DOI:
EISSN:
2397-7523
Language:
English
Keywords:
Source identifiers:
2201073
Deposit date:
2024-08-20
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