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Diurnal and circadian regulation of connexin 36 transcript and protein in the mammalian retina.

Abstract:

PURPOSE: Gap junctional coupling between rod and cone photoreceptor cells is regulated by light and the circadian clock, and contributes to retinal light adaptation. Phosphorylation of connexin 36 (Cx36) has been proposed as the mechanism involved. We investigated whether retinal Cx36 is also regulated at the level of transcript and protein expression. METHODS: At specific time points in a diurnal or circadian cycle, Cx36 protein was assessed by Western blotting and immunohistochemistry, and...

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Publication status:
Published

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Publisher copy:
10.1167/iovs.12-10375

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Journal:
Investigative ophthalmology and visual science
Volume:
54
Issue:
1
Pages:
821-829
Publication date:
2013-01-05
DOI:
EISSN:
1552-5783
ISSN:
0146-0404
URN:
uuid:94877fd3-4de7-4d4b-90d6-bd31dfb36765
Source identifiers:
374247
Local pid:
pubs:374247

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