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Schizophrenia susceptibility genes and their neurodevelopmental implications: focus on neuregulin 1.

Abstract:

On the basis of epidemiological as well as neurobiological evidence, schizophrenia has been conceptualized as a neurodevelopmental disorder. It is also known to have a large heritable component and a complex genetic architecture. Many putative susceptibility genes have recently been identified, arising both from positional cloning and candidate gene approaches. The evidence is strong for neuregulin 1, dysbindin and DISC1, and moderate for several others. However, there are key unanswered ques...

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Journal:
Novartis Foundation symposium
Volume:
288
Pages:
246-281
Publication date:
2007
EISSN:
1935-4657
ISSN:
1528-2511
URN:
uuid:947baa40-174a-4991-af15-879f9e6c7109
Source identifiers:
97907
Local pid:
pubs:97907

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