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Construction of genetic maps using distance geometry.

Abstract:

The techniques of distance geometry, which generate coordinates from observed interpoint distances, have been applied to the problem of determining the relative positions of linked genetic loci from observed interlocus distances. Only the most precise data needed to join the loci are used, with missing distances substituted by sums of precise intermediate distances. Good initial positions (and therefore the order) of loci on a linear map are obtained in an operation of complexity O(N3). The m...

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Publication status:
Published

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Publisher copy:
10.1006/geno.1995.0009

Authors


Newell, WR More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Lehrach, H More by this author
Journal:
Genomics
Volume:
30
Issue:
1
Pages:
59-70
Publication date:
1995-11-05
DOI:
EISSN:
1089-8646
ISSN:
0888-7543
URN:
uuid:9461cc8f-93af-4282-98a4-6fdca977a9be
Source identifiers:
73834
Local pid:
pubs:73834

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