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Hepatic and gut clearance of catecholamines in the conscious dog.

Abstract:

Our aim was to assess hepatic and gut catecholamine clearance under normal and simulated stress conditions. Following a 90-minute saline infusion period, epinephrine ([EPI] 180 ng/kg x min) and norepinephrine ([NE] 500 ng/kg x min) were infused peripherally for 90 minutes into five 18-hour fasted, conscious dogs undergoing a pancreatic clamp (somatostatin plus basal insulin and glucagon). Arterial plasma levels of EPI and NE increased from 44 +/- 9 to 2,961 +/- 445 and 96 +/- 6 to 6,467 +/- 5...

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Authors


Sindelar, DK More by this author
Cherrington, AD More by this author
Journal:
Metabolism: clinical and experimental
Volume:
48
Issue:
2
Pages:
259-263
Publication date:
1999-02-05
DOI:
EISSN:
1532-8600
ISSN:
0026-0495
URN:
uuid:94556a01-755d-4792-89cc-52a439d4539b
Source identifiers:
544610
Local pid:
pubs:544610

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