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Journal article

Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression

Abstract:

GTP cyclohydrolase I (GTPCH) catalyses the first and rate-limiting reaction in the synthesis of tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide synthases (NOS). Both eNOS and iNOS have been implicated in the progression of atherosclerosis, with opposing effects in eNOS and iNOS knockout mice. However, the pathophysiologic requirement for BH4 in regulating both eNOS and iNOS function, and the effects of loss of BH4 on the progression of atherosclerosis remains unknown.Hyperli...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/cvr/cvy078

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
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Publisher:
Oxford University Press Publisher's website
Journal:
Cardiovascular Research Journal website
Volume:
114
Issue:
10
Pages:
1385–1399
Publication date:
2018-03-27
Acceptance date:
2018-03-26
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
Pubs id:
pubs:833593
URN:
uri:944d9459-c97e-4a5c-9499-4099be6e809b
UUID:
uuid:944d9459-c97e-4a5c-9499-4099be6e809b
Local pid:
pubs:833593
Language:
English
Keywords:

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