Journal article
Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression
- Abstract:
-
GTP cyclohydrolase I (GTPCH) catalyses the first and rate-limiting reaction in the synthesis of tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide synthases (NOS). Both eNOS and iNOS have been implicated in the progression of atherosclerosis, with opposing effects in eNOS and iNOS knockout mice. However, the pathophysiologic requirement for BH4 in regulating both eNOS and iNOS function, and the effects of loss of BH4 on the progression of atherosclerosis remains unknown.Hyperli...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(pdf, 1.4MB)
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- Publisher copy:
- 10.1093/cvr/cvy078
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Authors
Funding
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Cardiovascular Research Journal website
- Volume:
- 114
- Issue:
- 10
- Pages:
- 1385–1399
- Publication date:
- 2018-03-27
- Acceptance date:
- 2018-03-26
- DOI:
- EISSN:
-
1755-3245
- ISSN:
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0008-6363
- Pmid:
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29596571
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:833593
- UUID:
-
uuid:944d9459-c97e-4a5c-9499-4099be6e809b
- Local pid:
- pubs:833593
- Deposit date:
- 2018-04-11
Terms of use
- Copyright holder:
- © Douglas, et al 2018 Published by Oxford University Press on behalf of the European Society of Cardiology
- Copyright date:
- 2018
- Notes:
- This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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