- Abstract:
-
We have isolated artificial ligands or aptamers for infectious prions in order to investigate conformational aspects of prion pathogenesis. The aptamers are 2'-fluoro-modified RNA produced by in vitro selection from a large, randomized library. One of these ligands (aptamer SAF-93) had more than 10-fold higher affinity for PrPSc than for recombinant PrPC and inhibited the accumulation of PrPres in near physiological cell-free conversion assay. To understand the molecular basis of these proper...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.m305297200
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 278
- Issue:
- 41
- Pages:
- 39697-39705
- Publication date:
- 2003-10-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:944b81ae-f9c2-459a-a5ab-c8fdc354096d
- Source identifiers:
-
3771
- Local pid:
- pubs:3771
- Copyright date:
- 2003
Journal article
Characterization of 2'-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion.
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