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The 5-HT(3) receptor antagonist alosetron inhibits the colorectal distention induced depressor response and spinal c-fos expression in the anaesthetised rat.

Abstract:

BACKGROUND: Noxious intestinal distention elicits a reflex depressor response in the sodium pentobarbitone anaesthetised rat, which can be used as an index of visceral nociception. 5-HT(3) receptor antagonists inhibit this reflex. Repeated colorectal distention (CRD) induces Fos like immunoreactivity (Fos-LI) in the rat spinal cord. AIMS: To examine the effect of the 5-HT(3) receptor antagonist alosetron on the depressor response to CRD, and on Fos expression in the lumbosacral spinal cord. ...

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Publication status:
Published

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Publisher copy:
10.1136/gut.46.4.474

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
Journal:
Gut
Volume:
46
Issue:
4
Pages:
474-480
Publication date:
2000-04-05
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:9447f574-43f6-4d4e-9318-00a025909dfa
Source identifiers:
31644
Local pid:
pubs:31644

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