Journal article icon

Journal article

A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition.

Abstract:

Human histocompatibility leukocyte antigen (HLA)-E is a nonclassical major histocompatibility complex (MHC) class I molecule which presents a restricted set of nonameric peptides, derived mainly from the signal sequence of other MHC class I molecules. It interacts with CD94/NKG2 receptors expressed on the surface of natural killer (NK) cells and T cell subsets. Here we demonstrate that HLA-E also presents a peptide derived from the leader sequence of human heat shock protein 60 (hsp60). This ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1084/jem.20020797

Authors


Michaëlsson, J More by this author
Teixeira de Matos, C More by this author
Lanier, LL More by this author
Expand authors...
Journal:
The Journal of experimental medicine
Volume:
196
Issue:
11
Pages:
1403-1414
Publication date:
2002-12-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:94450416-2398-4ab4-b5be-9b0928f5a07a
Source identifiers:
434241
Local pid:
pubs:434241

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP