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Journal article

Heat shock protein 27 functions in inflammatory gene expression and transforming growth factor-beta-activated kinase-1 (TAK1)-mediated signaling.

Abstract:

Heat shock protein (HSP) 27 has long been known to be a component of the p38 mitogen-activated protein kinase (MAPK) signaling pathway. p38 MAPK has important functions in the inflammatory response, but the role of HSP27 in inflammation has remained unknown. We have used small interfering RNAs to suppress HSP27 expression in HeLa cells and fibroblasts and found that it is required for pro-inflammatory cell signaling and the expression of pro-inflammatory genes. HSP27 is needed for the activat...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m610987200

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
The Journal of biological chemistry
Volume:
282
Issue:
9
Pages:
6232-6241
Publication date:
2007-03-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:943d175c-0c64-4b89-be73-39b7487ffbd6
Source identifiers:
224360
Local pid:
pubs:224360

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