Thesis icon

Thesis

New approaches to the investigation of the interactions between enhancers and promoters during haemopoiesis

Subtitle:
Development of the Next Generation Capture-C Assay for multiplexed analysis of chromatin conformation with greatly improved sensitivity
Abstract:

Next generation sequencing based methods allow us to identify active genes and potential regulatory elements rapidly across the genome, but an outstanding challenge is to unravel which regulatory elements control which genes. This is problematic because regulatory elements control genes over huge distances (over 1 million base pairs) and they have an unpredictable distribution around the genes they influence. In order to enhance transcription the protein complexes at distal regulatory elemen...

Expand abstract

Actions


Authors


More by this author
Department:
Weatherall Institute of Molecular Medicine

Contributors

Role:
Supervisor
Role:
Supervisor
More from this funder
Grant:
098931/Z/12/Z
Funding agency for:
James Davies
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP