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Plasma HDL cholesterol and risk of myocardial infarction: A mendelian randomisation study

Abstract:

Background High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian random isation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal. Methods We performed two mendelian randomisation analyses. First, we...

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Voight, BF More by this author
Voight, BF More by this author
Voight, BF More by this author
Voight, BF More by this author
Peloso, GM More by this author
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Journal:
The Lancet
Volume:
380
Issue:
9841
Pages:
572-580
Publication date:
2012-08-01
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:9433a9f2-3de9-4985-b08b-d72c954f9ff7
Source identifiers:
348834
Local pid:
pubs:348834

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