Journal article icon

Journal article

The induction of a nucleoplasmic reticulum by prelamin A accumulation requires CTP:phosphocholine cytidylyltransferase-α.

Abstract:

Farnesylated prelamin A accumulates when the final endoproteolytic maturation of the protein fails to occur and causes a dysmorphic nuclear phenotype; however, the morphology and mechanisms of biogenesis of these changes remain unclear. We show here that acute prelamin A accumulation after reduction in the activity of the ZMPSTE24 endoprotease by short interfering RNA knockdown, results in the generation of a complex nucleoplasmic reticulum that depends for its formation on the enzyme CTP:pho...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1242/jcs.091009

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of cell science
Volume:
124
Issue:
Pt 24
Pages:
4253-4266
Publication date:
2011-12-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:94233b8e-6e5c-4221-8a70-5c0b4c3e112f
Source identifiers:
237645
Local pid:
pubs:237645

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP