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HIV-1-neutralizing antibody induced by simian adenovirus- and poxvirus MVA-vectored BG505 native-like envelope trimers

Abstract:

Rabbits and monkeys immunized with HIV type 1 (HIV-1) native-like BG505 SOSIP.664 (BG505s) glycoprotein trimers are known to induce antibodies that can neutralize the autologous tier-2 virus. Here, we assessed the induction of HIV-1 trimer binding and neutralizing antibody (nAb) titres when BG505s trimers were also delivered by non-replicating simian (chimpanzee) adenovirus and non-replicating poxvirus modified vaccinia virus Ankara (MVA) vaccine vectors. First, we showed that approximately t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0181886

Authors


Capucci, S More by this author
More by this author
Department:
Oxford, MSD, NDM, Jenner Institute
Schiffner, T More by this author
LaBranche, CC More by this author
More by this author
Department:
Oxford, MSD, NDM, Jenner Institute
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European AIDS Vaccine Initiative More from this funder
Jenner Institute More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
12
Issue:
8
Pages:
e0181886
Publication date:
2017-08-05
Acceptance date:
2017-07-07
DOI:
ISSN:
1932-6203
Pubs id:
pubs:713198
URN:
uri:9418d88f-38e4-42be-a801-01d71c49c6c5
UUID:
uuid:9418d88f-38e4-42be-a801-01d71c49c6c5
Local pid:
pubs:713198
Language:
English
Keywords:

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