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Class I cross-restricted T cells reveal low responder allele due to processing of viral antigen.

Abstract:

Cytotoxic T lymphocytes (CTL) recognize protein antigens which have been processed by the target cell and then presented in association with the relevant class I molecule of the major histocompatibility complex (MHC). Short synthetic peptides, which are able to associate directly with target cells, may substitute for these processed fragments in stimulating antigen-specific CTL responses. Using this approach, a dominant HLA-A2-restricted epitope has previously been mapped to residues 58-68 of...

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Publication status:
Published

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Publisher copy:
10.1038/337653a0

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
Nature
Volume:
337
Issue:
6208
Pages:
653-655
Publication date:
1989-02-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:9414e5d9-01a2-4b48-ace8-df6d766ab457
Source identifiers:
35185
Local pid:
pubs:35185

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