Class I cross-restricted T cells reveal low responder allele due to processing of viral antigen.

Journal article

Cytotoxic T lymphocytes (CTL) recognize protein antigens which have been processed by the target cell and then presented in association with the relevant class I molecule of the major histocompatibility complex (MHC). Short synthetic peptides, which are able to associate directly with target cells, may substitute for these processed fragments in stimulating antigen-specific CTL responses. Using this approach, a dominant HLA-A2-restricted epitope has previously been mapped to residues 58-68 of...

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Authors: Bodmer, H; Gotch, F; Mcmichael, A

• Publication status: Published
• Journal: Nature
• Volume: 337
• Issue: 6208
• Pages: 653-655
• Publication date: 1989-02-01
• DOI: 10.1038/337653a0
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Amino Acid Sequence; Cells, Cultured; Protein Conformation; Humans; Cell Transformation, Viral; HLA-A Antigens; Genes, MHC Class I; Herpesvirus 4, Human; Antigens, Viral; T-Lymphocytes; Alleles