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Journal article

A genome scan in a single pedigree with a high prevalence of multiple sclerosis.

Abstract:

BACKGROUND: Multiple sclerosis (MS) is a disease that is widely believed to be autoimmune in nature. Genetic-epidemiological studies implicate susceptibility genes in the pathogenesis of MS, although non-MHC susceptibility linkages have been difficult to confirm. Insight into pathways that are intrinsic to other complex diseases has come from the genetic analysis of large, autosomal-dominant kindreds. Here, we present a genetic study of a large and unique kindred in which MS appears to follow...

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Publication status:
Published

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Publisher copy:
10.1136/jnnp.2007.122705

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Journal:
Journal of neurology, neurosurgery, and psychiatry
Volume:
79
Issue:
2
Pages:
158-162
Publication date:
2008-02-01
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
Source identifiers:
33876

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