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Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness

Abstract:

Sexual transmission of HIV-1 is an inefficient process, with only one or few variants of the donor quasispecies establishing the new infection. A critical, and as yet unresolved, question is whether the mucosal bottleneck selects for viruses with increased transmission fitness. Here, we characterized 300 limiting dilution-derived virus isolates from the plasma, and in some instances genital secretions, of eight HIV-1 donor and recipient pairs. Although there were no differences in the amount ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1073/pnas.1620144114

Authors


Bibollet-Ruche F More by this author
Sherrill-Mix, S More by this author
Learn, SGH More by this author
Plenderleith, L More by this author
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Funding agency for:
Iyer, SS
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Funding agency for:
Sherrill-Mix, S
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Funding agency for:
Barbian, HJ
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Funding agency for:
Russell, RM
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences of United States of America Journal website
Volume:
114
Issue:
4
Pages:
E590–E599
Publication date:
2017-01-09
Acceptance date:
2016-12-15
DOI:
ISSN:
1091-6490
Pubs id:
pubs:668725
URN:
uri:940ee0b9-0259-4e23-b8ba-e45963985f97
UUID:
uuid:940ee0b9-0259-4e23-b8ba-e45963985f97
Local pid:
pubs:668725

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