Journal article
Impaired Nociception in the Diabetic Ins2+/Akita Mouse
- Abstract:
-
The mechanisms responsible for painful and insensate diabetic neuropathy are not completely understood. Here, we have investigated sensory neuropathy in the Ins2+/Akita mouse, a hereditary model of diabetes. Akita mice become diabetic soon after weaning, and we show that this is accompanied by an impaired mechanical and thermal nociception and a significant loss of intraepidermal nerve fibers. Electrophysiological investigations of skin-nerve preparations identified a reduced rate of action p...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Accepted manuscript, pdf, 1.6MB)
-
- Publisher copy:
- 10.2337/db17-1306
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Bibliographic Details
- Publisher:
- American Diabetes Association Publisher's website
- Journal:
- Diabetes Journal website
- Volume:
- 67
- Issue:
- 8
- Pages:
- 1650-1662
- Publication date:
- 2018-06-06
- Acceptance date:
- 2018-05-18
- DOI:
- EISSN:
-
1939-327X
- ISSN:
-
0012-1797
- Pmid:
-
29875100
- Source identifiers:
-
983507
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:983507
- UUID:
-
uuid:94089662-af5d-4a66-853d-8fd3f6ad8f90
- Local pid:
- pubs:983507
- Deposit date:
- 2019-03-21
Terms of use
- Copyright holder:
- American Diabetes Association
- Copyright date:
- 2018
- Notes:
- © 2018 by the American Diabetes Association.
If you are the owner of this record, you can report an update to it here: Report update to this record