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Journal article

Impaired Nociception in the Diabetic Ins2+/Akita Mouse

Abstract:

The mechanisms responsible for painful and insensate diabetic neuropathy are not completely understood. Here, we have investigated sensory neuropathy in the Ins2+/Akita mouse, a hereditary model of diabetes. Akita mice become diabetic soon after weaning, and we show that this is accompanied by an impaired mechanical and thermal nociception and a significant loss of intraepidermal nerve fibers. Electrophysiological investigations of skin-nerve preparations identified a reduced rate of action p...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2337/db17-1306

Authors


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Role:
Author
ORCID:
0000-0003-0919-713X
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
ORCID:
0000-0002-7920-7877
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Role:
Author
ORCID:
0000-0001-5759-7985
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Publisher:
American Diabetes Association Publisher's website
Journal:
Diabetes Journal website
Volume:
67
Issue:
8
Pages:
1650-1662
Publication date:
2018-06-06
Acceptance date:
2018-05-18
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Pubs id:
pubs:983507
URN:
uri:94089662-af5d-4a66-853d-8fd3f6ad8f90
UUID:
uuid:94089662-af5d-4a66-853d-8fd3f6ad8f90
Local pid:
pubs:983507

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