- Abstract:
-
The mechanisms responsible for painful and insensate diabetic neuropathy are not completely understood. Here, we have investigated sensory neuropathy in the Ins2+/Akita mouse, a hereditary model of diabetes. Akita mice become diabetic soon after weaning, and we show that this is accompanied by an impaired mechanical and thermal nociception and a significant loss of intraepidermal nerve fibers. Electrophysiological investigations of skin-nerve preparations identified a reduced rate of action p...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Files:
-
-
(pdf, 1.6MB)
-
- Publisher copy:
- 10.2337/db17-1306
-
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- Publisher:
- American Diabetes Association Publisher's website
- Journal:
- Diabetes Journal website
- Volume:
- 67
- Issue:
- 8
- Pages:
- 1650-1662
- Publication date:
- 2018-06-06
- Acceptance date:
- 2018-05-18
- DOI:
- EISSN:
-
1939-327X
- ISSN:
-
0012-1797
- Pubs id:
-
pubs:983507
- URN:
-
uri:94089662-af5d-4a66-853d-8fd3f6ad8f90
- UUID:
-
uuid:94089662-af5d-4a66-853d-8fd3f6ad8f90
- Local pid:
- pubs:983507
- Language:
- English
- Keywords:
- Copyright holder:
- American Diabetes Association
- Copyright date:
- 2018
- Notes:
- © 2018 by the American Diabetes Association.
Journal article
Impaired Nociception in the Diabetic Ins2+/Akita Mouse
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