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High strength binding of P815 mastocytoma cells is not necessary for their lysis by macrophages which have been primed and triggered in vitro.

Abstract:

We have examined the hypothesis that binding of P815 mastocytoma cells is a necessary step in lysis of these cells by macrophages which are both "primed" and "triggered" in vitro, Macrophages "primed" by conditioned media containing IFN-gamma, or by rIFN-gamma have an increased ability to bind P815. However, adding either heat-killed Listeria or endotoxin to trigger the primed macrophages has opposite effects on lysis and binding of P815. Lysis is increased. Binding is dramatically decreased....

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
141
Issue:
4
Pages:
1083-1090
Publication date:
1988-08-29
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:93f8e0e9-42b8-42cb-9d34-6252e3886dd7
Source identifiers:
483521
Local pid:
pubs:483521

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