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Humoral and cellular immune responses to split-virion H5N1 influenza vaccine in young and elderly adults.

Abstract:

We evaluated the humoral and cellular immunogenicity of adjuvanted and non-adjuvanted H5N1 influenza vaccine in two groups of 300 adults: aged 18-60 and >60 years in a randomized, open-label, uncontrolled phase 2 trial. Participants received two injections (D0, D21) of 7.5 microg hemagglutinin without adjuvant or 30 microg with aluminum hydroxide adjuvant. Antibody responses and cytokine secretion were assessed before and after vaccination. Excluding the 6/300 non-elderly and 47/300 elderl...

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Publication status:
Published

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Authors


Leroux-Roels, I More by this author
Van der Wielen, M More by this author
Vandermeulen, C More by this author
Lazarus, R More by this author
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Journal:
Vaccine
Volume:
27
Issue:
49
Pages:
6918-6925
Publication date:
2009-11-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:93f6bff4-3297-46e2-9eba-411c367d0e31
Source identifiers:
119913
Local pid:
pubs:119913

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