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Thesis

Biomarkers of motor network excitability in amyotrophic lateral sclerosis

Alternative title:
Biomarkers of motor network excitability in ALS
Abstract:

Increased cortical excitability, associated with brain motor network alterations, has been consistently implicated in the pathology of amyotrophic lateral sclerosis (ALS). This thesis considers the application of multi-modal magnetic resonance imaging (MRI) to explore motor network excitability in ALS.

Chapter 3 describes a novel functional MRI (fMRI) study measuring motor task associated cortical activation and between-region functional connectivity in ALS. This showed hyper-activ...

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Role:
Supervisor
ORCID:
0000-0003-0267-3180
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Supervisor
ORCID:
0000-0002-5542-5036
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Name:
Dunhill Medical Trust
Funder identifier:
http://dx.doi.org/10.13039/501100000377
Grant:
HMR02450
Programme:
ABN/Dunhill medical trust clinical research training fellowship
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Name:
Association of British Neurologists
Grant:
HMR02450
Programme:
ABN/Dunhill medical trust clinical research training fellowship
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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