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A multiphase model for tissue construct growth in a perfusion bioreactor.

Abstract:

The growth of a cell population within a rigid porous scaffold in a perfusion bioreactor is studied, using a three-phase continuum model of the type presented by Lemon et al. (2006, Multiphase modelling of tissue growth using the theory of mixtures. J. Math. Biol., 52, 571-594) to represent the cell population (and attendant extracellular matrix), culture medium and porous scaffold. The bioreactor system is modelled as a 2D channel containing the cell-seeded rigid porous scaffold (tissue cons...

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Publication status:
Published

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Publisher copy:
10.1093/imammb/dqp003

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Journal:
Mathematical medicine and biology : a journal of the IMA
Volume:
27
Issue:
2
Pages:
95-127
Publication date:
2010-06-05
DOI:
EISSN:
1477-8602
ISSN:
1477-8599
URN:
uuid:93e1ec13-b800-4dbd-8d67-36b8d27aa8a8
Source identifiers:
60574
Local pid:
pubs:60574

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