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Evaluation of tubulin polymerization and chronic inhibition of proteasome as citotoxicity mechanisms in bortezomib-induced peripheral neuropathy.

Abstract:

Bortezomib (BTZ) is the first proteasome inhibitor entered in clinical practice. Peripheral neuropathy is likely to be a class side effect of these drugs, although its severity is largely variable, and it deserves to be further investigated, since the mechanisms of BTZ-induced peripheral neurotoxicity (BiPN) are still unknown.   In our study, we investigated in vivo and in vitro possible pathogenic events relevant to BiPN using a well-established rat model, with particular reference to the ex...

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Publication status:
Published

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Publisher copy:
10.4161/cc.27476

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Journal:
Cell cycle (Georgetown, Tex.)
Volume:
13
Issue:
4
Pages:
612-621
Publication date:
2014-02-05
DOI:
EISSN:
1551-4005
ISSN:
1538-4101
URN:
uuid:93de8648-92b2-4b53-a2e3-c11a8ba87689
Source identifiers:
457637
Local pid:
pubs:457637

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