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An immunohistological study of desmosomal components in pemphigus.

Abstract:

Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune diseases in which there is loss of cohesion between keratinocytes (acantholysis) and blistering within the epidermis. PV is characterized by acantholysis predominantly between the epidermal basal cells and suprabasal layers, whereas in PF intraepidermal cleavage is higher in the epidermis. Adhesion between keratinocytes is dependent on the function of transmembrane glycoproteins of the cadherin family present in specialized a...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
The British journal of dermatology
Volume:
128
Issue:
4
Pages:
363-370
Publication date:
1993-04-05
DOI:
EISSN:
1365-2133
ISSN:
0007-0963
URN:
uuid:93dd04ba-36b2-4b72-be9e-d6336fce4c95
Source identifiers:
22279
Local pid:
pubs:22279

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