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Corticotrophin releasing factor: responses in normal subjects and patients with disorders of the hypothalamus and pituitary.

Abstract:

Synthetic CRF-41 has been given to 43 patients with hypothalamic, pituitary or adrenal diseases and contrasted with the responses in 20 normal subjects. In the normal subjects the mean increment in serum cortisol (+/- SE) was 276 +/- 38 nmol/l; the increments showed a significant negative correlation with the basal serum cortisol levels (r = -0.56; P less than 0.02). The mean peak serum cortisol was 662 +/- 34 nmol/l and the mean peak corticosterone was 28.6 +/- 3.8 nmol/l. There was a signif...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
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Journal:
Clinical endocrinology
Volume:
20
Issue:
1
Pages:
71-84
Publication date:
1984-01-05
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
URN:
uuid:93d82abe-14e3-49e2-a1b2-c284a0a88732
Source identifiers:
138606
Local pid:
pubs:138606

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