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The multifarious role of microglia in brain metastasis

Abstract:

The immune landscape in brain metastasis is a very heterogeneous framework. Amongst a broad plethora of cells within the tumor microenvironment, the presence of activated microglia has been perfectly described. The innate role of microglial cells is to detect and eliminate any insults that may disturb the regular behavior of the brain. As part of its defensive role, it releases pro- and anti-inflammatory cytokines that aim to modulate the inflammatory scenario at the metastatic foci. However,...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Subgroup:
CRUK/MRC Ox Inst Radiation Oncology
ORCID:
0000-0003-1211-2766
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Cellular Neuroscience Journal website
Volume:
12
Pages:
Article: 414
Publication date:
2018-11-12
Acceptance date:
2018-10-23
ISSN:
1662-5102
Pubs id:
pubs:935887
URN:
uri:93ce79aa-1e40-463e-b72a-ec34813bfc6d
UUID:
uuid:93ce79aa-1e40-463e-b72a-ec34813bfc6d
Local pid:
pubs:935887

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