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Association of the influenza A virus RNA-dependent RNA polymerase with cellular RNA polymerase II.

Abstract:

Transcription by the influenza virus RNA-dependent RNA polymerase is dependent on cellular RNA processing activities that are known to be associated with cellular RNA polymerase II (Pol II) transcription, namely, capping and splicing. Therefore, it had been hypothesized that transcription by the viral RNA polymerase and Pol II might be functionally linked. Here, we demonstrate for the first time that the influenza virus RNA polymerase complex interacts with the large subunit of Pol II via its...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of virology
Volume:
79
Issue:
9
Pages:
5812-5818
Publication date:
2005-05-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:93a71f9a-b375-42b3-b8ce-2ce13a97aa8e
Source identifiers:
23691
Local pid:
pubs:23691

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