Journal article icon

Journal article

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy

Abstract:

The blood system is maintained by a small pool of haematopoietic stem cells (HSCs), which are required and sufficient for replenishing all human blood cell lineages at millions of cells per second throughout life. Megakaryocytes in the bone marrow are responsible for the continuous production of platelets in the blood, crucial for preventing bleeding - a common and life-threatening side effect of many cancer therapies - and major efforts are focused at identifying the most suitable cellular a...

Expand abstract

Actions


Access Document


Publisher copy:
10.1038/nature12495

Authors


Sanjuan-Pla, A More by this author
Macaulay, IC More by this author
Jensen, CT More by this author
Expand authors...
Journal:
Nature
Volume:
502
Issue:
7470
Pages:
232-236
Publication date:
2013
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:93a12fd8-7445-4b9c-b41a-2de7633d2cc0
Source identifiers:
436382
Local pid:
pubs:436382
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP