- Abstract:
-
Accumulating evidence suggests that alloreactive memory T cells (Tm) may form a barrier to tolerance induction in large animals and humans due in part to a resistance to suppression by Treg. However, why Tm are resistant to regulation and how the Tm response to an allograft differs from that of naïve T cells, which are amenable to suppression by Treg, remains unknown. Here, we show that accelerated graft rejection mediated by CD8(+) Tm was due to the enhanced recruitment of PMN to allografts ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/eji.201040671
-
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- Journal:
- European journal of immunology
- Volume:
- 40
- Issue:
- 11
- Pages:
- 3107-3116
- Publication date:
- 2010-11-05
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- URN:
-
uuid:9380c0d3-8b74-4d19-953a-da3a2bda40f6
- Source identifiers:
-
135996
- Local pid:
- pubs:135996
- Copyright date:
- 2010
Journal article
Regulatory T cells can prevent memory CD8+ T-cell-mediated rejection following polymorphonuclear cell depletion.
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