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Regulatory T cells can prevent memory CD8+ T-cell-mediated rejection following polymorphonuclear cell depletion.

Abstract:

Accumulating evidence suggests that alloreactive memory T cells (Tm) may form a barrier to tolerance induction in large animals and humans due in part to a resistance to suppression by Treg. However, why Tm are resistant to regulation and how the Tm response to an allograft differs from that of naïve T cells, which are amenable to suppression by Treg, remains unknown. Here, we show that accelerated graft rejection mediated by CD8(+) Tm was due to the enhanced recruitment of PMN to allografts ...

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Publication status:
Published

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Publisher copy:
10.1002/eji.201040671

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
Journal:
European journal of immunology
Volume:
40
Issue:
11
Pages:
3107-3116
Publication date:
2010-11-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:9380c0d3-8b74-4d19-953a-da3a2bda40f6
Source identifiers:
135996
Local pid:
pubs:135996

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