Journal article icon

Journal article

Pervasive influence of hepatitis C virus on the phenotype of antiviral CD8+ T cells.

Abstract:

Recent studies using MHC class I tetramers have shown that CD8(+) T cell responses against different persistent viruses vary considerably in magnitude and phenotype. At one extreme, hepatitis C virus (HCV)-specific CD8(+) T cell responses in blood are generally weak and have a phenotype that is perforin low and CCR7 high (early memory). At the other, specific responses to CMV are strong, perforin high, and CCR7 low (mature or effector memory). To examine the potential mechanisms behind this d...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.4049/jimmunol.172.3.1744

Authors


Vargas-Cuero, AL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Expand authors...
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
172
Issue:
3
Pages:
1744-1753
Publication date:
2004-02-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:93807462-a989-4c73-9098-6951a9a59fb5
Source identifiers:
29683
Local pid:
pubs:29683

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP