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Effect of corticosteroids on human osteoclast formation and activity.

Abstract:

Chronic corticosteroid treatment is known to induce bone loss and osteoporosis. Osteoclasts are specialised bone-resorbing cells that are formed from mononuclear phagocyte precursors that circulate in the monocyte fraction. In this study we have examined the effect of the synthetic glucocorticoid, dexamethasone, on human osteoclast formation and bone-resorbing activity. Human monocytes were cultured for up to 21 days on glass coverslips and dentine slices, with soluble receptor activator for ...

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Publication status:
Published

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Publisher copy:
10.1677/joe.0.1750155

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Journal of endocrinology
Volume:
175
Issue:
1
Pages:
155-163
Publication date:
2002-10-01
DOI:
EISSN:
1479-6805
ISSN:
0022-0795
Source identifiers:
103835
Language:
English
Keywords:
Pubs id:
pubs:103835
UUID:
uuid:937dd85e-cf6e-4e7d-9b6f-2d60af07f6bb
Local pid:
pubs:103835
Deposit date:
2012-12-19

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