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Broad-spectrum CC-chemokine blockade by gene transfer inhibits macrophage recruitment and atherosclerotic plaque formation in apolipoprotein E-knockout mice.

Abstract:

BACKGROUND: The CC-chemokines (CKs) recruit monocytes/macrophages to sites of inflammation; several different CC-CKs play a role in the pathogenesis of atherosclerosis. The vaccinia virus expresses a 35-kDa soluble protein (35K) that binds to and inactivates nearly all of the CC-CKs, providing a potentially useful therapeutic strategy for broad-spectrum CC-CK inhibition in atherosclerosis. A recombinant adenovirus encoding soluble 35K (Ad35K) was generated to investigate the effect of 35K ge...

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Publication status:
Published

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Authors


Bursill, CA More by this author
Choudhury, RP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School, BHF Centre of Research Excellence
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Journal:
Circulation
Volume:
110
Issue:
16
Pages:
2460-2466
Publication date:
2004-10-05
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
URN:
uuid:936ea223-c533-4bd8-bdb6-293b991fd0fa
Source identifiers:
16848
Local pid:
pubs:16848

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