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Genotype-dependent effects of COMT inhibition on cognitive function in a highly-specific, novel mouse model of altered COMT activity

Abstract:

Catechol-O-methyltransferase (COMT) modulates dopamine levels in the prefrontal cortex (PFC). The human gene contains a polymorphism (Val158Met) that alters enzyme activity and influences PFC function. It has also been linked with cognition and anxiety, but findings are mixed. We therefore developed a novel mouse model of altered COMT activity. The human Met allele was introduced into the native mouse COMT gene to produce COMT-Met mice, which were compared to their wild-type littermates. The...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/npp.2016.119

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
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More from this funder
Funding agency for:
Tunbridge, E
Grant:
087736
More from this funder
Funding agency for:
Tunbridge, E
Grant:
087736
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Grant:
studentships
087736
Publisher:
Nature Publishing Group Publisher's website
Journal:
Neuropsychopharmacology Journal website
Publication date:
2016-07-08
Acceptance date:
2016-06-30
DOI:
EISSN:
1740-634X
ISSN:
0893-133X
Source identifiers:
632188
Pubs id:
pubs:632188
UUID:
uuid:936cc722-8d43-4d32-be3b-720beb16a1e0
Local pid:
pubs:632188
Deposit date:
2016-07-05

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