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Serotonin transporters in depression

Abstract:

Major depression is a common, recurrent and severe mental illness and is a leading cause of medical disability worldwide. The pathophysiology of depression is not well understood but evidence strongly suggests that dysfunction in brain serotonin (5-HT) neurons may play a significant role. The serotonin transporter (5-HTT) recycles released 5-HT back into neurons and is a key regulator of 5-HT neurotransmission. Abnormality in the 5-HTT has been proposed as an important mechanism in the eti...

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Division:
MSD
Department:
Psychiatry
Role:
Author

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Supervisor
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Name:
Medical Research Council
Funding agency for:
Cowen, P
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
DOI:

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