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Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans.

Abstract:

Protective immunity against Mycobacterium tuberculosis depends on the generation of a T(H)1-type cellular immune response, characterized by the secretion of interferon-gamma (IFN-gamma) from antigen-specific T cells. The induction of potent cellular immune responses by vaccination in humans has proven difficult. Recombinant viral vectors, especially poxviruses and adenoviruses, are particularly effective at boosting previously primed CD4(+) and CD8(+) T-cell responses against a number of intr...

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Publication status:
Published

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Publisher copy:
10.1038/nm1128

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
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Journal:
Nature medicine
Volume:
10
Issue:
11
Pages:
1240-1244
Publication date:
2004-11-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:9352e8c2-433b-471f-8894-a01e962aa886
Source identifiers:
32885
Local pid:
pubs:32885

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