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Journal article

Constitutively active ALK2 receptor mutants require type II receptor cooperation.

Abstract:

Constitutively activating mutations in receptor kinases recruit downstream effector pathways independently of upstream signaling, with consequences ranging from developmental syndromes to cancer. Classic fibrodysplasia ossificans progressiva (FOP) is a congenital syndrome resulting from highly conserved activating mutations of the glycine-serine-rich (GS) regulatory domain of ACVR1, encoding bone morphogenetic protein (BMP) type I receptor ALK2, which lead to inappropriate signaling and hete...

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Publication status:
Published

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Publisher copy:
10.1128/mcb.01595-12

Authors


Bagarova, J More by this author
Vonner, AJ More by this author
Armstrong, KA More by this author
Börgermann, J More by this author
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Journal:
Molecular and cellular biology
Volume:
33
Issue:
12
Pages:
2413-2424
Publication date:
2013-06-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:934c5136-f4a2-401f-85b0-a7ecaec7d87a
Source identifiers:
394922
Local pid:
pubs:394922

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