Constitutively active ALK2 receptor mutants require type II receptor cooperation.
Constitutively activating mutations in receptor kinases recruit downstream effector pathways independently of upstream signaling, with consequences ranging from developmental syndromes to cancer. Classic fibrodysplasia ossificans progressiva (FOP) is a congenital syndrome resulting from highly conserved activating mutations of the glycine-serine-rich (GS) regulatory domain of ACVR1, encoding bone morphogenetic protein (BMP) type I receptor ALK2, which lead to inappropriate signaling and hete...Expand abstract
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- Note: an erratum exists for this article, originally published and available at: https://doi.org/10.1128/MCB.00284-17
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