Journal article icon

Journal article

The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome

Abstract:

The inactive X chromosome (Xi) in female mammals adopts an atypical higher-order chromatin structure, manifested as a global loss of local topologically associated domains (TADs), A/B compartments and formation of two mega-domains. Here we demonstrate that the non-canonical SMC family protein, SmcHD1, which is important for gene silencing on Xi, contributes to this unique chromosome architecture. Specifically, allelic mapping of the transcriptome and epigenome in SmcHD1 mutant cells reveals t...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

Actions


Access Document


Files:
Publisher copy:
10.1038/s41467-018-07907-2

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
ORCID:
0000-0001-7740-4386
Pintacuda, G More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Expand authors...
More from this funder
Funding agency for:
Kriaucionis, S
More from this funder
Funding agency for:
Brockdorff, N
More from this funder
Funding agency for:
Brockdorff, N
Publisher:
Nature Research Publisher's website
Journal:
Nature Communications Journal website
Volume:
10
Pages:
Article: 30
Publication date:
2019-01-03
Acceptance date:
2018-11-14
DOI:
EISSN:
2041-1723
Pubs id:
pubs:946283
URN:
uri:9346140d-5152-4290-a517-929d6073dda3
UUID:
uuid:9346140d-5152-4290-a517-929d6073dda3
Local pid:
pubs:946283

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP