- Abstract:
-
A T helper cell type 1-mediated colitis develops in severe combined immunodeficient mice after transfer of CD45RB(high) CD4(+) T cells and can be prevented by cotransfer of the CD45RB(low) subset. The immune-suppressive activities of the CD45RB(low) T cell population can be reversed in vivo by administration of an anti-transforming growth factor beta antibody. Here we show that interleukin (IL)-10 is an essential mediator of the regulatory functions of the CD45RB(low) population. This populat...
Expand abstract - Publisher copy:
- 10.1084/jem.190.7.995
-
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- Journal:
- The Journal of experimental medicine
- Volume:
- 190
- Issue:
- 7
- Pages:
- 995-1004
- Publication date:
- 1999-10-05
- DOI:
- EISSN:
-
1540-9538
- ISSN:
-
0022-1007
- URN:
-
uuid:932f52a8-af69-4d38-8c6b-ae9739943cf4
- Source identifiers:
-
14395
- Local pid:
- pubs:14395
- Language:
- English
- Keywords:
- Copyright date:
- 1999
Journal article
An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation.
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