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An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation.

Abstract:

A T helper cell type 1-mediated colitis develops in severe combined immunodeficient mice after transfer of CD45RB(high) CD4(+) T cells and can be prevented by cotransfer of the CD45RB(low) subset. The immune-suppressive activities of the CD45RB(low) T cell population can be reversed in vivo by administration of an anti-transforming growth factor beta antibody. Here we show that interleukin (IL)-10 is an essential mediator of the regulatory functions of the CD45RB(low) population. This populat...

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Publisher copy:
10.1084/jem.190.7.995

Authors


Journal:
The Journal of experimental medicine
Volume:
190
Issue:
7
Pages:
995-1004
Publication date:
1999-10-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:932f52a8-af69-4d38-8c6b-ae9739943cf4
Source identifiers:
14395
Local pid:
pubs:14395

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