- Abstract:
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Peptide macrocycles are promising therapeutic molecules because they are protease resistant, structurally rigid, membrane permeable and capable of modulating protein-protein interactions. Here, we report the characterization of the dual function macrocyclase-peptidase enzyme involved in the biosynthesis of the highly toxic Amanitin toxin family of macrocycles. The enzyme first removes 10 residues from the N-terminus of a 35-residue substrate. Conformational trapping of the 25 amino acid pepti...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.0MB)
-
- Publisher copy:
- 10.1038/s41467-017-00862-4
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- Funding agency for:
- Ludewig, H
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 8
- Issue:
- 1045
- Pages:
- 1-10
- Publication date:
- 2017-10-19
- Acceptance date:
- 2017-08-02
- DOI:
- ISSN:
-
2041-1723
- Pubs id:
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pubs:710162
- URN:
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uri:9319d7a6-06b5-48ca-94f6-9fe19bdc9295
- UUID:
-
uuid:9319d7a6-06b5-48ca-94f6-9fe19bdc9295
- Local pid:
- pubs:710162
- Copyright holder:
- © Czekster, et al 2017
- Copyright date:
- 2017
- Notes:
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Journal article
Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates
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+ Engineering and Physical Sciences Research Council
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