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The structure and evolution of the human beta-globin gene family.

Abstract:

We present the results of a detailed comparison of the primary structure of human beta-like globin genes and their flanking sequences. Among the sequences located 5' to these genes are two highly conserved regions which include the sequences ATA and CCAAT located 31 +/- 1 and 77 +/- 10 bp, respectively, 5' to the mRNA capping site. Similar sequences are found in the corresponding locations in most other eucaryotic structural genes. Calculation of the divergence times of individual beta-like g...

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Publication status:
Published

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Authors


Efstratiadis, A More by this author
Posakony, JW More by this author
Maniatis, T More by this author
O'Connell, C More by this author
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Journal:
Cell
Volume:
21
Issue:
3
Pages:
653-668
Publication date:
1980-10-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:93140ddb-aeaa-4f2f-bab0-8391b88b1c68
Source identifiers:
18703
Local pid:
pubs:18703

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