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Journal article

Open-state models of a potassium channel.

Abstract:

The structure of the bacterial potassium channel, KcsA, corresponds to the channel in a closed state. Two lines of evidence suggest that the channel must widen its intracellular mouth when in an open state: 1) internal block by a series of tetraalkylammonium ions and 2) spin labeling experiments. Thus it is known that the protein moves in this region, but it is unclear by how much and the mechanisms that are involved. To address this issue we have applied a novel approach to generate plausibl...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1016/s0006-3495(02)73951-9

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Biophysical journal Journal website
Volume:
83
Issue:
4
Pages:
1867-1876
Publication date:
2002-10-01
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Source identifiers:
99868
Language:
English
Keywords:
Pubs id:
pubs:99868
UUID:
uuid:93128413-f452-4b71-8e4d-a2efc384c688
Local pid:
pubs:99868
Deposit date:
2012-12-19

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