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Journal article

HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load.

Abstract:

Human immunodeficiency virus type 1 (HIV-1) mutations that confer escape from cytotoxic T-lymphocyte (CTL) recognition can sometimes result in lower viral fitness. These mutations can then revert upon transmission to a new host in the absence of CTL-mediated immune selection pressure restricted by the HLA alleles of the prior host. To identify these potentially critical recognition points on the virus, we assessed HLA-driven viral evolution using three phylogenetic correction methods across f...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.02455-07

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Journal:
Journal of virology
Volume:
82
Issue:
13
Pages:
6434-6446
Publication date:
2008-07-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:930efb53-8797-47e1-9f68-6f4de99d8d12
Source identifiers:
191195
Local pid:
pubs:191195

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