Journal article
The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritis.
- Abstract:
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During rheumatoid arthritis there is enlargement and increased cellularity of the synovial lining of joints, before invasion by the synovium of the underlying cartilage and bone. This increased tissue mass requires a network of blood vessels to supply nutrients and oxygen. Disruption of synovial angiogenesis is thus a desirable aim of antiarthritic therapies. Protease-activated kringles 1-5 (K1-5) is an angiogenesis inhibitor related to angiostatin. In common with angiostatin, K1-5 contains t...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 417.8KB, Terms of use)
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- Publisher copy:
- 10.1186/ar608
Authors
Bibliographic Details
- Publisher:
- BioMed Central
- Journal:
- Arthritis research and therapy More from this journal
- Volume:
- 5
- Issue:
- 1
- Pages:
- R32-R39
- Publication date:
- 2002-10-31
- DOI:
- EISSN:
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1478-6362
- ISSN:
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1478-6354
Item Description
- Language:
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English
- Keywords:
- UUID:
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uuid:930a7e56-936a-4bc6-8ca5-825e4bbfa9bb
- Local pid:
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pubs:224873
- Source identifiers:
-
224873
- Deposit date:
-
2012-12-19
Terms of use
- Copyright holder:
- Sumariwalla et al
- Copyright date:
- 2002
- Notes:
- © 2002 Sumariwalla et al., licensee BioMed Central Ltd. This article is published in Open Access:verbatim copying and redistribution of this article are permitted in all media for any non-commercial purpose, provided this notice is preserved along with the article's original URL. The electronic version of this article is the complete one and can be found online at: http://arthritis-research.com/content/5/1/R32
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