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The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritis.

Abstract:

During rheumatoid arthritis there is enlargement and increased cellularity of the synovial lining of joints, before invasion by the synovium of the underlying cartilage and bone. This increased tissue mass requires a network of blood vessels to supply nutrients and oxygen. Disruption of synovial angiogenesis is thus a desirable aim of antiarthritic therapies. Protease-activated kringles 1-5 (K1-5) is an angiogenesis inhibitor related to angiostatin. In common with angiostatin, K1-5 contains t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/ar608

Authors


Sumariwalla, PF More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Paleolog, EM More by this author
Arthritis Research Campaign More from this funder
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
Arthritis research and therapy Journal website
Volume:
5
Issue:
1
Pages:
R32-R39
Publication date:
2002-10-31
DOI:
EISSN:
1478-6362
ISSN:
1478-6354
URN:
uuid:930a7e56-936a-4bc6-8ca5-825e4bbfa9bb
Source identifiers:
224873
Local pid:
pubs:224873

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