Journal article
Allosteric site on SHIP2 identified through fluorescent ligand screening and crystallography: a potential new target for intervention
- Abstract:
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Src homology 2 domain-containing inositol phosphate phosphatase 2 (SHIP2) is one of the 10 human inositol phosphate 5-phosphatases. One of its physiological functions is dephosphorylation of phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4,5)P3. It is therefore a therapeutic target for pathophysiologies dependent on PtdIns(3,4,5)P3 and PtdIns(3,4)P2. Therapeutic interventions are limited by the dearth of crystallographic data describing ligand/inhibitor binding. An active site-directed fl...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Supplementary materials, 2.2MB, Terms of use)
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(Preview, Version of record, 8.4MB, Terms of use)
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- Publisher copy:
- 10.1021/acs.jmedchem.0c01944
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Funding
Bibliographic Details
- Publisher:
- American Chemical Society
- Journal:
- Journal of Medicinal Chemistry More from this journal
- Volume:
- 64
- Issue:
- 7
- Pages:
- 3813–3826
- Publication date:
- 2021-03-16
- Acceptance date:
- 2021-02-19
- DOI:
- EISSN:
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1520-4804
- ISSN:
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0022-2623
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1162362
- Local pid:
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pubs:1162362
- Deposit date:
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2021-02-19
Terms of use
- Copyright holder:
- Whitfield et al.
- Copyright date:
- 2021
- Rights statement:
- Copyright © 2021 The Authors. Published by American Chemical Society.
- Licence:
- CC Attribution (CC BY)
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