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A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress.

Abstract:

Renal fibrosis is a common feature of renal failure resulting from multiple etiologies, including diabetic nephropathy, hypertension and inherited renal disorders. However, the mechanisms of renal fibrosis are incompletely understood and we therefore explored these by establishing a mouse model for a renal tubular disorder, referred to as autosomal dominant tubulointerstitial kidney disease (ADTKD) due to missense uromodulin (UMOD) mutations (ADTKD-UMOD). ADTKD-UMOD, which is associated with ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1242/dmm.029488

Authors


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Department:
Oxford, MSD, RDM, OCDEM
Olinger, E More by this author
Nesbit, MA More by this author
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Kidney Research UK More from this funder
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Grant:
Senior Investigator Award
Luxembourg National Research Fund More from this funder
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Publisher:
Company of Biologists Publisher's website
Journal:
Disease Models & Mechanisms Journal website
Volume:
10
Issue:
6
Pages:
773-786
Publication date:
2017-03-05
Acceptance date:
2017-03-02
DOI:
EISSN:
1754-8411
ISSN:
1754-8403
Pubs id:
pubs:686826
URN:
uri:92fa566e-8644-4630-9596-b8c1c15a6110
UUID:
uuid:92fa566e-8644-4630-9596-b8c1c15a6110
Local pid:
pubs:686826

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