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Journal article

CD8+ T cell epitope-flanking mutations disrupt proteasomal processing of HIV-1 Nef.

Abstract:

CTL play a critical role in the control of HIV and SIV. However, intrinsic genetic instability enables these immunodeficiency viruses to evade detection by CTL through mutation of targeted antigenic sites. These mutations can impair binding of viral epitopes to the presenting MHC class I molecule or disrupt TCR-mediated recognition. In certain regions of the virus, functional constraints are likely to limit the capacity for variation within epitopes. Mutations elsewhere in the protein, howeve...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.175.7.4618

Authors


Milicic, A More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
175
Issue:
7
Pages:
4618-4626
Publication date:
2005-10-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:92ee64e0-b7a7-43fb-9943-3e9014a76dfd
Source identifiers:
5484
Local pid:
pubs:5484

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