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The Safety and Efficacy of Mineralocorticoid Receptor Antagonists in Patients Who Require Dialysis: A Systematic Review and Meta-analysis.

Abstract:

Patients who require dialysis are at high risk for cardiovascular mortality, which may be improved by mineralocorticoid receptor antagonists (MRAs).Systematic review and meta-analysis of randomized controlled trials.Adults undergoing long-term hemodialysis or peritoneal dialysis with or without heart failure.Randomized controlled trials evaluating an MRA in dialysis and reported at least one outcome of interest.Spironolactone (8 trials) or eplerenone (1 trial) compared to placebo (7 trials) o...

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Publication status:
Published

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Publisher copy:
10.1053/j.ajkd.2016.04.011

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Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
Role:
Author
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Contributors

Department:
Department of Clinical Epidemiology and Biostatistics, McMaster University, Ontario, Canada.
/Canadian Institutes of Health Research More from this funder
/Academic Medical Organization of Southwestern Ontario More from this funder
Journal:
American journal of kidney diseases : the official journal of the National Kidney Foundation
Issue:
4
Publication date:
2016-10-05
DOI:
ISSN:
0272-6386 and 1523-6838
Pubs id:
pubs:628421
URN:
uri:92e70303-517e-415f-8c82-95e2d6296dee
UUID:
uuid:92e70303-517e-415f-8c82-95e2d6296dee
Local pid:
pubs:628421

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